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Point-of-care genetic testing for personalisation of antiplatelet treatment

Rapid Gene: A prospective, randomised, proof-of-concept trial

  • Rapid genetic testing after PCI can be effectively done at the bedside to identify CYP2C19*2 LOF allele carriers
  • This prospective, randomized 200-patient study reported that tailored, genotype-guided treatment of CYP2C19*2 carriers can reduce high on-treatment platelet reactivity, which is commonly associated with increased risk for major adverse cardiovascular events
  • This study is the first reported use of an FDA-cleared, rapid CYP2C19 genetic test, and offers a novel solution to overcome limitations in pharmacogenomics

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